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| classical complement pathway ： ウィキペディア英語版 |
classical complement pathway
The Classical pathway of activation of the complement system is a group of blood proteins that mediate the specific antibody response. The main activators of the Classical Pathway are antigen-antibody complexes.
== Initiation ==
It is triggered by antigen-bound antibody molecules. (The only antibodies capable of binding are two units of IgG or one IgM, although IgM is more effective at activating complement. IgG4 cannot bind, but the other three IgG types can.) It is the binding of Fc region to the C1 component that initiates this pathway. The classical pathway can also be triggered by binding of C1 to some types of structures on the target microbe. Also, it can be triggered by C-Reactive Protein binding to microbic polysaccharides such as phosphocholine.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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